Patee House Museum is St. Joseph's only National Historic Landmark. It has been listed by True West magazine as one of America's Top 10 Western Museums in 2008, and it is one of 1,000 Places to See in the U.S.A. & Canada Before You Die.
Built in 1858 as a luxury hotel, Patee House served as the Pony Express headquarters from 1860 to 1861. It is one block away from the home of infamous outlaw Jesse James, where he was shot and killed by Bob Ford. After his death, the James family stayed and were interviewed in the hotel.